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❌❓ THE CHALLENGE: Glycans hide the tumor in disguise. ➡ Typical cancer-specific Tumor Glycocodes render the tumor invisible to the immune system, they stay ‘cold’. Intelligently, glycans from that Tumor Glycocode are not present on neighbouring healthy tissue, rendering it a perfect target for eradication & potential use as biomarker for patient selection and treatment response. ➡ So far, efforts to break that code for therapeutic benefits have been unsuccessful. One reason for this is the dynamic shape & motion of glycans, and the inability to manufacture them ex vivo. ⭕❗ THE SOLUTION: Conjugated Glycopeptides. Gnubiotics’ proprietary technology conjugates O-glycans with short protein parts - peptides - ex vivo to form novel glycopeptides that are druggable targets amenable to mass production. 🔜 Breaking the Tumor Glycocode. Since 2019, multiple preclinical models have demonstrated proof of concept for the lead compound GNU101 to be orally bioavailable, resisting degradation, and surviving enzyme proteolysis. The preclinical body of evidence has demonstrated proof-of-concept that the GENESIS platform based glycopeptides are able to turn 'cold' into 'hot' tumors, breaking through I/O resistance and inducing tumor cell killing. 💡 THE TEAM: We are a highly specialized team of Founders, Scientists and Entrepreneurs pursuing the transition from a large basis of preclinical evidence into IND-readiness and the clinics with First-in-human clinical phase 1 study for colorectal cancer patients in 2024/2025. 📥 Curious to learn more? Check out our new website and contacts 🌐 https://gnubiotics.com/
The Gnutti Carlo Group is world leader in the automotive sector. It is partner of several OEM's that are active in the auto, truck, earthmoving, motorcycle, marine, generator sets, and e-mobility sectors. With a turnover of 700 million Euros and more than 4,000 employees, the company based in Maclodio (Brescia - Italy) has travelled around the world: 14 plants in 9 countries, in Europe, America and Asia. Gnutti Carlo was founded in 1922, at the beginning of the last century as a company producing agricultural components. After a series of reconversions, in the mid-80s, the production of engine components began, specializing in rocker arms and diesel injection components that gave life to the POWERTRAIN Division. In 2014, Gnutti Carlo acquired the Ljunghall Group founded in 1917 and European leader in the supply of complex aluminum components for the automotive and telecommunications sector. The Ljunghall Group became the LIGHT METALS Division capable of supplying the market with complete valve train systems (camshaft carrier + rocker arm assembly). The Light Metals Division was already well positioned in e-mobility with important projects in collaboration with major global players. In 2018, the Gnutti Carlo Group created a new production area with the acquisition of the Austrian TCG Unitech, which later became the TCG UNITECH Division, a leading company in the production of die-cast technical components in light metals (aluminum and magnesium) thermoplastic injection moulding and the development and production of oil pumps and coolant pumps. In addition, through TCG Unitech, Gnutti Carlo significantly increased its presence in the premium cars sector.
GNV operates on 33 maritime routes connecting Italy (including Sardinia and Sicily), Tunisia, Algeria, Morocco, Spain, France, Albania, and Malta. Destinations include Genoa, Civitavecchia, Naples, Palermo, Termini Imerese, Olbia, Porto Torres, Barcelona, Valencia, Palma de Mallorca, Ibiza, Mahón, Almería, Tunis, Tangier, Algiers, Bejaia, Nador, Sète, Bari, Durrës, and Malta. GNV is also actively engaged in the development of "maritime motorways of the sea", positioning sea transport as a cost-effective alternative to traditional road transport. This innovative approach not only reduces transportation costs but also provides an efficient solution to the environmental challenges associated with heavy lorry traffic on national road networks. 6 domestic lines in SICILY Genova-Palermo Civitavecchia-Palermo Civitavecchia-Termini Imerese Napoli-Palermo Napoli-Termini Imerese Genova-Termini Imerese (freight only) 3 domestic lines in SARDINIA Civitavecchia-Olbia Genova-Olbia Genova-Porto Torres 3 international lines in TUNISIA Genova-Tunisi Civitavecchia-Tunisi Palermo-Tunisi 2 international lines in ALGERIA Sète - Algiers, Sète - Bejaia, 6 international lines in BALEARICS Barcellona-Mahón Barcellona-Palma di Maiorca Palma di Maiorca-Ibiza Palma di Maiorca-Mahón Valencia-Ibiza Valencia-Palma di Maiorca 6 international lines in MAROCCO Genova-Tangeri Sete-Tangeri Sete-Nador Barcellona-Tangeri Barcellona-Nador Genova-Barcellona 1 international line in ALBANIA Bari-Durazzo 2 international lines in MALTA (freight only) Genova-Malta Palermo-Malta
Gnvonline Kit Gás is a retail company based out of Rua Farias Brito, Rio De Janeiro, Rj, Brazil.
İhtiyaç duyulan enerjinin yaklaşık %72sini ithal eden ülkemizde 16 milyondan fazla yalıtımsız konut bulunmakta ve bu mevcut binaların %80inin yalıtımsız olduğu anlamına gelmektedir. Yalıtımı bulunmayan binalar sebebi ile enerji boşa harcanmakta ve her yıl bu harcamanın ülke ekonomisine bedeli milyarlarca doları bulmaktadır. Binalarda enerji kaybını ısı yalıtım uygulamaları ile %50 oranında azaltmak mümkündür. Bu gerçekten hareketle enerjide dışa bağımlılığımızın azalması ve enerji israfının önüne geçilmesi konusunda sergilediğimiz vatandaşlık bilinciyle 2008 yılından bu yana yalıtım sektöründe her yıl ciddi büyüme oranları yakalayarak 4 milyon m² nin üzerinde enerji yalıtımı gerçekleştirmiş bir firmayız.
Comprehensive enterprise dossier available in global intelligence registry.
We’re a Fractional CFO + Accounting Firm that works with Fast-Growth Companies… Our clients have innovative and industry leading products, who are looking to gain market access and drive new revenues. Industries Served Software as a Service | Technology | Manufacturing | Professional Services | Engineering | Architecture | Data Science | Digital Marketing | Property Management | Food Service | Online Retail
Comprehensive enterprise dossier available in global intelligence registry.
Comprehensive enterprise dossier available in global intelligence registry.
Go Adventure is a tourist agency from Split, Croatia specialized in adventure tours in Dalmatian region. With over 10.000 happy guests on a yearly basis, though still being young, Go Adventure is one of the most successful and acknowledged tourist agencies in Dalmatia. Agency`s success is built on innovation, professionalism and high quality services, all led by a team of young talented people.
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